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E3 Ligand-Linker Conjugate 8
CAS No. 1957235-74-3
E3 Ligand-Linker Conjugate 8( —— )
Catalog No. M13068 CAS No. 1957235-74-3
An E3 ligase ligand-linker conjugate for PROTAC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameE3 Ligand-Linker Conjugate 8
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NoteResearch use only, not for human use.
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Brief DescriptionAn E3 ligase ligand-linker conjugate for PROTAC.
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DescriptionAn E3 ligase ligand-linker conjugate for PROTAC.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetE3 Ligase Ligand
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RecptorE3 Ligase Ligand
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1957235-74-3
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Formula Weight462.459
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Molecular FormulaC21H26N4O8
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCN
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Chemical NameN-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lohbeck J, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262.
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